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Immunoglobulin deficiency syndromes are a group of disorders that involve defects of any component of the immune system or a defect of another system that affects the immune system, leading to an increased incidence or severity of infection. In these disorders, specific diseasefighting antibodies (immunoglobulins such as IgG, IgA, and IgM) are either missing or are present in reduced levels. Children who have immunodeficiency syndromes may be subject to infection, diseases, disorders, or allergic reactions to a greater extent than individuals with fully functioning immune systems.

 

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Immunodeficiency is a defect of any component of the immune system or a defect of another system that affects the immune system leading to an increased incidence or severity of infection. Immunoglobulin deficiencies refer to missing or reduced levels of immunoglobulin (IgG, IgA, IgM) associated with an inability to make adequate specific antibody. These antibodies are specific proteins (immunoglobulins) produced by the immune system to respond to bacteria, viruses, fungi, parasites, or toxins that invade the body

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  • Immunoglobulin G (IgG) is the most abundant class of immunoglobulins, directed toward viruses, bacterial organisms, and toxins. It is found in most tissues and in plasma, the clear portion of blood.

  • Immunoglobulin M (IgM) is the first antibody produced in an immune response to any invading organism or toxic substance.

  • Immunoglobulin A (IgA) is activated early in response to invasion by bacteria and viruses. It is found in saliva, tears, and all other mucus secretions.

  • As of the early 2000s, IgD activity is not well understood.

  • Immunoglobulin E (IgE) is found in respiratory secretions and is directed toward invasion of the body by parasites and in allergic reactions such as hay fever, atopic dermatitis , and allergic asthma .

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